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52nd ERA-EDTA Congress

 

28-31 May 2015 London
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Discussion forum - 52nd ERA-EDTA Congress
    Topic - J2) Chronic Kidney Disease. Pathophysiology, progression & risk factors.

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Poster: 273
Visits: 30
Title: FIBROBLAST GROWTH FACTOR 23 MODULATES ANGIOTENSIN RECEPTOR BLOCKADE EFFICACY IN EXPERIMENTAL RENAL FIBROSIS
Authors: Maarten de Jong , Mirkovic K, van den Born J, Navis GJ, de Borst MH
Centre: University Medical Center Groningen

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FIBROBLAST GROWTH FACTOR 23 MODULATES ANGIOTENSIN RECEPTOR BLOCKADE EFFICACY IN EXPERIMENTAL RENAL FIBROSIS

Maarten de Jong
Thread initiator
Subspeciality
Reg: 5/18/2015 4:17:00 PM
Comment# 1
It has been hypothesized that cross-talk between the phosphaturic hormone Fibroblast growth factor 23 (FGF23) and the renin-angiotensin-aldosteron system (RAAS) may decrease the renoprotective effect of RAAS-blockade, thus contributing to treatment resistance in CKD patients. We have investigated this potential interaction using the unilateral ureteral obstruction model of renal fibrosis. UUO Mice were treated mouse recombinant FGF23 (160ug/kg intraperitoneally twice daily) or vehicle, combined with either angiotensin receptor blockade (ARB; losartan, 100mg/L in drinking water) or vehicle. We have observed that FGF23 co-treatment modified the pharmacological effects of angiotensin receptor blockade. However, this interaction did not result in significant impediment of the renoprotective efficacy. Possibly, the effect of FGF23 was limited due to severe downregulation of its co-factor Klotho.

Comment added on 5/18/2015 4:17:00 PM 
     
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Most viewed poster for this congress
Poster: 625
Visits: 3858
Title: IS 4 CITRATE AN EFFECTIVE TOOL AS A CATHETER LOCKING SOLUTION?
Authors: Joao Fazendeiro Matos ,
Centre: Fresenius Medical Care | NephroCare Portugal

Poster most viewed in this topic
Poster: 295
Visits: 118
Title: RISK FACTORS FOR PROGRESSION TO DIALYSIS AND USE OF ACEI IN CKD STAGE 5
Authors: Pamela Gallo , Dattolo P Romoli E Michelassi S Mehmetaj A Tsalouchos A Fani F Pizzarelli F
Centre: Santa Maria Annunziata Hospital


 






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